AMG 319
货号：
17383-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17383-1mg |
| 描述 | AMG 319 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform δ (PI3Kδ; IC50 = 18 nM) that less effectively targets the α, β, and γ isoforms (IC50s = 33, 2.7, and 0.85 µM, respectively).1 It blocks anti-IgM/CD40L-induced proliferation (IC50 = 8.6 nM) and reduces Akt phosphorylation (IC50 = 1.5 nM) in B cells.1 AMG 319 is orally bioavailable and reduces inflammation in two animal models.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Cushing, T.D.,Hao, X.,Shin, Y., et al. Discovery and in vivo evaluation of (S)-N-(1-(7-fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and related PI3Kδ inhibitors for inflammation and autoimmune disease. J. Med. Chem. 58(1), 480-511 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 385.4 |
| 分子式 | C21H16FN7 |
| CAS号 | 1608125-21-8 |
| 稳定性 | ≥ 2 years |
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