Fexaramine
货号：
17369-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17369-1mg |
| 描述 | The farnesoid X receptor (FXR) is a nuclear receptor that acts as a bile acid sensor, protecting cells and organs against bile acid toxicity and coordinating cholesterol metabolism, lipid homeostasis, and absorption of dietary fats and vitamins. Fexaramine is an FXR agonist (EC50 = 25 nM) that demonstrates 100-fold increased affinity to FXR compared to endogenous bile acids and 3-fold increased potency compared to the high affinity FXR agonist GW 4064 (Item No. 10006611; EC50 = 80 nM).1 Fexaramine does not display activity at the following nuclear receptors: hRXRα, hPPARαγδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ, or hVDR.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Downes, M.,Verdecia, M.A.,Roecker, A.J., et al. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Molecular Cell 11(4), 1079-1092 (2003).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 496.6 |
| 分子式 | C32H36N2O3 |
| CAS号 | 574013-66-4 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
