A-61603
货号：
17358-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17358-1mg |
| 描述 | The α1-adrenergic receptors are Gq protein-coupled receptors that play a key role in the modulation of sympathetic nervous system activity and are the site of action for therapeutic agents, such as antihypertensive drugs. A-61603 is a selective α1A-adrenergic receptor agonist that is at least 35-fold more potent at α1A receptor sites than at α1B or α1D.1 Activation of the α1A-adrenergic receptor by A-61603 has been reported to increase the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro(EC50 = 6.9 nM) much more potently than activation by phenylephrine (Item No. 17205; EC50 = 2.3 µM).2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Meyer, M.D.,Altenbach, R.J.,Hancock, A.A., et al. Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: A novel selective α1A receptor agonist. Journal of Medicinal Chemistry 39(20), 4116-4119 (1996).
2.Luo, D.l.,Gao, J.,Fan, L.l., et al. Receptor subtype involved in α1-adrenergic receptor-mediated Ca2+ signaling in cardiomyocytes. Acta.Pharmacol.Sin. 28(7), 968-974 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 390.3 |
| 分子式 | C14H19N3O3S • HBr |
| CAS号 | 107756-30-9 |
| 稳定性 | ≥ 2 years |
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