Verteporfin
货号：
17334-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17334-1mg |
| 描述 | Verteporfin is a photosensitizer used during photodynamic therapy to eliminate abnormal blood vessels in the eye that are associated with conditions such as macular degeneration. It accumulates in these abnormal blood vessels and, when activated by nonthermal red light with a wavelength of 693 nm in the presence of oxygen, produces a highly reactive short-lived singlet oxygen and other reactive oxygen radicals, generating local damage to the endothelium and vessel occlusion.1 Verteporfin can also inhibit autophagosome formation by directly targeting and modifying p62, a scaffold and adaptor protein that binds both polyubiquitinated proteins destined for degradation and LC3 on autophagosomal membranes.2 |
| 别名 | BPD-MA;CL 318,952; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schmidt-Erfurth, U., and Hasan, T. Mechanisms of action of photodynamic therapy with verteporfin for the treatment of age-related macular degeneration. Survey of Ophthalmology 45(3), 195-214 (2000).
2.Donohue, E.,Balgi, A.D.,Komatsu, M., et al. Induction of covalently crosslinked p62 oligomers with reduced binding to polyubiquitinated proteins by the autophagy inhibitor verteporfin. PLoS One 9(12), 1-30 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 718.8 |
| 分子式 | C41H42N4O8 |
| CAS号 | 129497-78-5 |
| 稳定性 | ≥ 2 years |
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