| 货号 | 17295-1g |
| 描述 | Fendiline is an α2-adrenergic receptor antagonist (Kd = 2.6 µM) and an L-type calcium channel blocker (IC50 = 17 µM) well-known for its coronary vasodilator effects.1,2,3,4 Fendiline has recently been reported to inhibit K-Ras plasma membrane localization (IC50 = 9.64 µM), which prevents K-Ras signal transduction and blocks the proliferation of K-Ras-transformed tumor cells.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Motulsky, H.J.,Snavely, M.D.,Hughes, R.J., et al. Interaction of verapamil and other calcium channel blockers with α1- and α2-adrenergic receptors. Circulation Research 52(2), 226-231 (1983). 2.Nawrath, H.,Klein, G.,Rupp, J., et al. Open state block by fendiline of L-type Ca++ channels in ventricular myocytes from rat heart. Journal of Pharmacology and Experimental Therapeutics 285(2), 546-552 (1998). 3.Tripathi, O.,Schreibayer, W., and Tritthart, H.A. Fendiline inhibits L-type calcium channels in guinea-pig ventricular myocytes: A whole-cell patch-clamp study. British Journal of Pharmacology 108(4), 865-869 (1993). 4.Csik, V.,Szekeres, L., and Udvary, E. Comparison of two calcium antagonists, verapamil and fendiline, in an experimental model of myocardial ischaemia mimicking classical angina on effort. British Journal of Pharmacology 79(1), 37-43 (1983). 5.van der Hoven, D.,Cho, K.J.,Ma, X., et al. Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Molecular and Cellular Biology 33(2), 237-251 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 351.9 |
| 分子式 | C23H25N • HCl |
| CAS号 | 13636-18-5 |
| 稳定性 | ≥ 2 years |
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