| 货号 | 17291-50mg |
| 描述 | (S)-(-)-Propranolol is the active enantiomer of propranolol, a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively.1,2 It is also a non-specific serotonin receptor antagonist.3 Propanolol was one of the first β-adrenergic receptor blockers to be widely used in clinical practice for the treatment of hypertension, angina pectoris, and cardiac ischemia.1,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005). 2.Mehvar, R., and Brocks, D.R. Stereospecific pharmacokinetics and pharmacodynamics of β-adrenergic blockers in humans. J. Pharm. Pharm. Sci. 4(2), 185-200 (2001). 3.Costain, D.W., and Green, A.R. β-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamine. British Journal of Pharmacology 64(2), 193-200 (1978). 4.Gerber, J.G.,Freed, C.R., and Nies, A.S. Antihypertensive pharmacology. West.J.Med. 132(5), 430-439 (1980). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 295.8 |
| 分子式 | C16H21NO2 • HCl |
| CAS号 | 839971 |
| 稳定性 | ≥ 2 years |
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