GSK1016790A
货号：
17289-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17289-1mg |
| 描述 | Transient receptor potential vanilloid 4 (TRPV4) is a nonselective cation channel thought to be involved in osmoregulation, hyperalgesia, and control of epithelial cell volume. GSK1016790A is a TRPV4 agonist that has been reported to elicit calcium influx in HEK cells expressing mouse or human TRPV4 (EC50s = 18 and 2.1 nM, respectively).1 It has been used to demonstrate a role for TRPV4 in regulating urinary bladder activity and endothelial control of vascular tone.1,2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Thorneloe, K.S.,Sulpizio, A.C.,Lin, Z., et al. N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I. Journal of Pharmacology and Experimental Therapeutics 326(2), 432-442 (2008).
2.Willette, R.N.,Bao, W.,Nerurkar, S., et al. Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2. Journal of Pharmacology and Experimental Therapeutics 326(2), 443-452 (2008).
3.Adapala, R.K.,Talasila, P.K.,Bratz, I.N., et al. PKCα mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells. American Journal of Physiology.Heart and Circulatory Physiology 301(3), H757-H765 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 655.6 |
| 分子式 | C28H32Cl2N4O6S2 |
| CAS号 | 942206-85-1 |
| 稳定性 | ≥ 2 years |
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