| 货号 | 17273-1g |
| 描述 | Furosemide is an inhibitor of the Na+/K+/2Cl- (NKCC) cotransporters, NKCC1 and NKCC2 (Ki = ~10 µM for each).1,2 It is commonly used as a loop diuretic, blocking NKCC2 action on the apical membrane of the thick ascending limb of Henle epithelial cells.2 Furosemide also acts as an antagonist of GABAA receptors and as an inhibitor of carbonic anhydrase and organic anion transporter 1.3,4,5 |
| 别名 | Frusemide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Gillen, C.M.,Brill, S.,Payne, J.A., et al. Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. The Journal of Biological Chemisty 271(27), 16237-16244 (1996). 2.Markadieu, N., and Delpire, E. Physiology and pathophysiology of SLC12A1/2 transporters. Pflugers.Arch. 466(1), 91-105 (2014). 3.Korpi, E.R., and Lüddens, H. Furosemide interactions with brain GABAA receptors. British Journal of Pharmacology 120(5), 741-748 (1997). 4.Temperini, C.,Cecchi, A.,Scozzafava, A., et al. Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct. Bioorganic & Medicinal Chemistry Letters 18(8), 2567-2573 (2008). 5.Uwai, Y.,Saito, H.,Hashimoto, Y., et al. Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1. Journal of Pharmacology and Experimental Therapeutics 295(1), 261-265 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 330.7 |
| 分子式 | C12H11ClN2O5S |
| CAS号 | 54-31-9 |
| 稳定性 | ≥ 2 years |
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