NU 6140
货号：
17271-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 17271-500ug |
| 描述 | NU 6140 is a cyclin-dependent kinase 2 (Cdk2) inhibitor (IC50 = 0.41 μM) that demonstrates 10- to 36-fold selectivity against Cdk2-cyclin A compared to Cdk1-cyclin B, Cdk4-cyclin D, Cdk5-p25, or Cdk7-cyclin H.1 NU 6140 has been found to induce cell-cycle arrest at the G2-M phase and to potentiate the apoptotic effect of paclitaxel (Item No. 10461) in HeLa cells by inhibiting the anti-apoptotic protein, survivin.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pennati, M.,Campbell, A.J.,Curto, M., et al. Potentiation of paclitaxel-induced apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: A possible role for survivin down-regulation. Molecular Cancer Therapeutics 4(9), 1328-1337 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 422.5 |
| 分子式 | C23H30N6O2 |
| CAS号 | 444723-13-1 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
