WAY-161503
货号：
17269-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17269-1mg |
| 描述 | WAY-161503 is a full agonist of 5-HT2C receptors (Ki = 3.3 nM for displacement of DOI (Item No. 13885)).1 Relative to 5-HT2C receptor binding, WAY-161503 is ~6-fold less potent at 5-HT2Areceptors (Ki = 18 nM) and 20-fold less potent at 5-HT2B receptors (Ki = 60 nM).1 In functional studies, WAY-161503 can stimulate calcium mobilization coupled to 5-HT2C, 2B,and2A receptors with EC50 values of 0.8, 1.8, and 7 nM, respectively.1 WAY-161503 has been reported to produce dose-dependent decreases in food intake in 24-hour fasted normal Sprague-Dawley rats, diet-induced obese mice, and obese Zucker rats with ED50 values of 1.9, 6.8, and 0.73 mg/kg, respectively.1 This compound has been used to examine the role of 5-HT2C receptors in rodent models of depression, locomotion, reinforcement, or motivated behaviors.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rosenzweig-Lipson, S.,Zhang, J.,Mazandarani, H., et al. Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503. Brain Research 1073-1074, 240-251 (2006).
2.Cryan, J.F., and Lucki, I. Antidepressant-like behavioral effects mediated by 5-Hydroxytryptamine(2C) receptors. Journal of Pharmacology and Experimental Therapeutics 295(3), 1120-1126 (2000).
3.Hayes, D.J.,Mosher, T.M., and Greenshaw, A.J. Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats. Behavioural Brain Research 197(2), 323-330 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 272.1 |
| 分子式 | C11H11Cl2N3O |
| CAS号 | 75704-24-4 |
| 稳定性 | ≥ 2 years |
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