| 货号 | 17268-1mg |
| 描述 | Calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is involved in calcium homeostasis.1,2 Calhex 231 is a negative allosteric modulator of CaSR that blocks calcium-mediated activation (IC50 = 0.39 µM).3 It also attenuates the activation of CaSR by calcimimetics, like calindol (Item No. 17575) and R-568.4,5 Calhex 231 is commonly used to study the role of CaSR in various cell types, including stem cells.4,5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Nemeth, E.F. The search for calcium receptor antagonists (calcilytics). Journal of Molecular Endocrinology 29, 15-21 (2002). 2.Filopanti, M.,Corbetta, S.,Barbieri, A.M., et al. Pharmacology of the calcium sensing receptor. Clin.Cases Miner.Bone Metab. 10(3), 162-165 (2013). 3.Petrel, C.,Kessler, A.,Maslah, F., et al. Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor. The Journal of Biological Chemisty 278(49), 49487-49494 (2015). 4.Weston, A.H.,Absi, M.,Ward, D.T., et al. Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: Studies with calindol and Calhex 231. Circulation Research 97(4), 391-398 (2005). 5.Di Tomo, P.,Pipino, C.,Lanuti, P., et al. Calcium sensing receptor expression in ovine amniotic fluid mesenchymal stem cells and the potential role of R-568 during osteogenic differentiation. PLoS One 8(9), 1-12 (2013). 6.Lembrechts, R.,Brouns, I.,Schnorbusch, K., et al. Functional expression of the multimodal extracellular calcium-sensing receptor in pulmonary neuroendocrine cells. Journal of Cell Science 126(19), 4490-4501 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 407 |
| 分子式 | C25H27ClN2O |
| CAS号 | 652973-93-8 |
| 稳定性 | ≥ 2 years |
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