| 货号 | 17260-1mg |
| 描述 | IC261 is a reversible, ATP-competitive inhibitor of casein kinase 1 (CK1) that inhibits CK1δ and CK1ɛ (IC50 = ~1 µM for both), as well as CK1α (IC50 = 16 µM).1 It is at least 100-fold less effective against PKA, p34cdc2, and p55fyn.1 IC 261, at 1 µM, inhibits cytokinesis in primary mouse embryo fibroblasts.2 IC261 is used to elucidate the role of CK1 in cells and in whole organisms.3,4,5 |
| 别名 | SU5607; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Mashhoon, N.,DeMaggio, A.J.,Tereshko, V., et al. Crystal structure of a conformation-selective casein kinase-1 inhibitor. The Journal of Biological Chemisty 275(26), 20052-20060 (2000). 2.Behrend, L.,Milne, D.M.,Stöter, M., et al. IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effects. Oncogene 19(47), 5303-5313 (2000). 3.van Ooijen, G.,Martin, S.F.,Barrios-Llerena, M.E., et al. Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular alga. BMC Cell Biology 14, (2013). 4.Rachidi, N.,Taly, J.F.,Durieu, E., et al. Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection. Antimicrobial Agents and Chemotherapy 58(3), 1501-1515 (2014). 5.Kurihara, T.,Sakurai, E.,Toyomoto, M., et al. Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors. Molecular Pain 10, (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 311 |
| 分子式 | C18H17NO4 |
| CAS号 | 186611-52-9 |
| 稳定性 | ≥ 2 years |
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