| 货号 | 17250-1g |
| 描述 | (R,S)-Atenolol is a β1-adrenergic receptor antagonist with Ki values of 1.14 and 48.7 µM for β1 and β2, respectively.1 It has been reported that only the (S) enantiomer contributes to the beta-blocking effects of racemic atenolol.2,3 Beta-blockers, including atenolol, have diverse applications in cardiology and vascular disease.4 |
| 别名 | Duraatenol;IC I66082;Tenormin®; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Golf, S.,Bjornerheim, R.,Erichsen, A., et al. Relative selectivity of different β-adrenoceptor antagonists for human heart β1- and β2-receptor subtypes assayed by a radioligand binding technique. Scandinavian Journal of Clinical and Laboratory Investigation 47(7), 719-723 (1987). 2.Stoschitzky, K.,Egginger, G.,Zernig, G., et al. Stereoselective features of (R)- and (S)-atenolol: Clinical pharmacological, pharmacokinetic, and radioligand binding studies. Chirality 5(1), 15-19 (1993). 3.Mehvar, R., and Brocks, D.R. Stereospecific pharmacokinetics and pharmacodynamics of β-adrenergic blockers in humans. J. Pharm. Pharm. Sci. 4(2), 185-200 (2001). 4.Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 266.3 |
| 分子式 | C14H22N2O3 |
| CAS号 | 29122-68-7 |
| 稳定性 | ≥ 2 years |
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