| 货号 | 17236-5mg |
| 描述 | Glucosylceramide synthase catalyzes the transfer of glucose to ceramide to generate glucosylceramide, the first step in glycosphingolipid synthesis.1DL-threo-PPMP is a ceramide analog that inhibits glucosylceramide synthase with an IC50 value between 2 and 20 µM.2 It has been used to study the role of glucosylceramide synthase in cell growth, apoptosis, and autophagy.2,3,4,5 |
| 别名 | DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Shayman, J.A. The design and clinical development of inhibitors of glycosphingolipid synthesis: Will invention be the mother of necessity? Trans.Am.Clin.Climatol.Assoc. 124, 46-60 (2013). 2.Abe, A.,Inokuchi, J.-i.,Jimbo, M., et al. Improved inhibitors of glucosylceramide synthase. J. Biochem. 111, 191-196 (1992). 3.Rani, C.S.S.,Abe, A.,Chang, Y., et al. Cell cycle arrest induced by an inhibitor of glucosylceramide synthase. Correlation with cyclin-dependent kinases. The Journal of Biological Chemisty 270(6), 2859-2867 (1995). 4.Watters, R.J.,Fox, T.E.,Tan, S.F., et al. Targeting glucosylceramide synthase synergizes with C6-ceramide nanoliposomes to induce apoptosis in natural killer cell leukemia. Leukemia and Lymphoma 54(6), 1288-1296 (2013). 5.Shen, W.,Henry, A.G.,Paumier, K.L., et al. Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons. J. Neurochem. 129(5), 884-894 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 511.2 |
| 分子式 | C29H50N2O3 • HCl |
| CAS号 | 139974-41-7 |
| 稳定性 | ≥ 2 years |
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