9-amino Camptothecin
货号：
17232-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17232-1mg |
| 描述 | DNA topoisomerases relax supercoiled DNA during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks represents a target for anticancer agents to intercalate between DNA base pairs, leading to the activation of apoptotic and cell cycle arrest pathways.1 9-amino Camptothecin is a topoisomerase I inhibitor that was developed as a more water-soluble analog of camptothecin (Item No. 11694).2,3 It is cytotoxic to HT-29 cells at an IC50 value of 19 nM, induces DNA damage in whole cells at a concentration of 85 nM, and demonstrates significant anti-tumor activity in clinical studies.2,3 |
| 别名 | NSC 603071; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Drwal, M.N.,Agama, K.,Wakelin, L.P.G., et al. Exploring DNA topoisomerase I ligand space in search of novel anticancer agents. PLoS One 6(9), 1-12 (2011).
2.Rothenberg, M.L. Topoisomerase I inhibitors: Review and update. Annals of Oncology 8(9), 837-855 (1997).
3.Dancey, J., and Eisenhauer, E.A. Current perspectives on camptothecins in cancer treatment. Br. J. Cancer 74(3), 327-338 (1996).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 363.4 |
| 分子式 | C20H17N3O4 |
| CAS号 | 91421-43-1 |
| 稳定性 | ≥ 2 years |
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