| 货号 | 17205-500mg |
| 描述 | L-Phenylephrine is an adrenergic α1A receptor agonist (Ki = 1.4 µM) that demonstrates selectivity against the α1B and α1C receptor subtypes (Kis = 23.9 and 47.8 µM, respectively).1 By stimulating adrenergic α1 receptors, L-phenylephrine can induce aortic smooth muscle contractions, although reported relative affinity and potency values in rabbit are 5-fold weaker compared to that of L-norepinephrine.2 This compound is frequently used to precontract smooth muscle in preparations designed to study the properties of various vasodilator agents.3,4 Because L-phenylephrine acts on adrenergic α1 receptors in the arterioles of the nasal mucosa to produce constriction, it has been examined clinically as an oral decongestant.5 |
| 别名 | (R)-(-)-Phenylephrine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lomasney, J.W.,Cotecchia, S.,Lorenz, W., et al. Molecular cloning and expression of the cDNA for the α1A-adrenergic receptor. The gene for which is located on human chromosome 5. The Journal of Biological Chemisty 266(10), 6365-6369 (1991). 2.Besse, J.C., and Furchgott, R.F. Dissociation constants and relative efficacies of agonists acting on alpha adrenergic receptors in rabbit aorta. Journal of Pharmacology and Experimental Therapeutics 197(1), 66-78 (1976). 3.Dogan, M.,Peker, R.O.,Donmez, S., et al. Magnesium and diltiazem relaxes phenylephrine-precontracted rat aortic rings. Interact.Cardiovasc.Thorac.Surg. 15(1), 1-4 (2012). 4.Brunsden, A.M.,Brookes, S.J.H.,Bardhan, K.D., et al. Mechanisms underlying mechanosensitivity of mesenteric afferent fibers to vascular flow. American Journal of Physiology and Gastrointestinal Liver Physiology 293(2), G422-G428 (2007). 5.Hatton, R.C.,Winterstein, A.G.,McKelvey, R.P., et al. Efficacy and safety of oral phenylephrine: Systematic review and meta-analysis. Annals of Pharmacotherapy 41(3), 381-390 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 167.2 |
| 分子式 | C9H13NO2 |
| CAS号 | 59-42-7 |
| 稳定性 | ≥ 2 years |
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