Ifenprodil (hemitartrate)
货号：
17201-5mg 基本售价：
350.0 元 规格：
5 mg
产品信息
概述| 货号 | 17201-5mg |
| 描述 | Ifenprodil is a selective antagonist of NMDA receptors that contain NR2B subunits (IC50 = 0.3 µM) and displays 150-fold weaker activity at those bearing NR2C or NR2D subunits.1 Ifenprodil also acts as a potent ligand at receptors for σ1, emopamil binding proteins, and their σ-like, fungal counterpart ERG2 (Kis = 2, 5, and 1 nM).2 This compound has been described as an α-adrenergic vasodilator, but is also reported to constrict cerebrovascular smooth muscle in vitro(EC50 = 2.4 µM).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bräuner-Osborne, H.,Egebjerg, J.,Nielsen, E.O., et al. Ligands for glutamate receptors: Design and therapeutic prospects. J. Med. Chem. 43(14), 2609-2645 (2000).
2.Laggner, C.,Schieferer, C.,Fiechtner, B., et al. Discovery of high-affinity ligands of σ1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. Journal of Medicinal Chemistry 48(15), 4754-4764 (2005).
3.Young, A.R.,Bouloy, M.,Boussard, J.F., et al. Direct vascular effects of agents used in the pharmacotherapy of cerebrovascular disease on isolated cerebral vessels. Journal of Cerebral Blood Flow and Metabolism 1(1), 117-128 (1981).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 400.5 |
| 分子式 | C21H27NO2 • 1/2C4H6O6 |
| CAS号 | 23210-58-4 |
| 稳定性 | ≥ 2 years |
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