| 货号 | 17185-100mg |
| 描述 | Tazobactam is an inhibitor of β-lactamases with greater activity against Ambler class A serine penicillinases and class C cephalosporinases, including TEM-1, SHV-1, and P99 (IC50s = 97, 150, and 8.5 nM).1,2 It also inhibits the class D oxacillinase OXA-2 (IC50 = 10 nM).2 Tazobactam is commonly paired with piperacillin, although it also supports other cephalosporin antibiotics.2,3,4 |
| 别名 | CL-307579;YTR 830; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Arnoff, S.C.,Jacobs, M.R.,Johenning, S., et al. Comparative activities of the β-lactamase inhibitors YTR 830, sodium clavulanate, and sulbactam combined with amoxicillin or ampicillin. Antimicrobial Agents and Chemotherapy 26(4), 580-582 (1984). 2.Drawz, S.M., and Bonomo, R.A. Three decades of β-lactamase inhibitors. Clin.Microbiol.Rev. 23(1), 160-201 (2010). 3.Falagas, M.E.,Tansarli, G.S.,Ikawa, K., et al. Clinical outcomes with extended or continuous versus short-term intravenous infusion of carbapenems and piperacillin/tazobactam: A systematic review and meta-analysis. Clinical Infectious Diseases 56(2), 272-282 (2013). 4.Hong, M.C.,Hsu, D.I., and Bounthavong, M. Ceftolozane/tazobactam: A novel antipseudomonal cephalosporin and β-lactamase-inhibitor combination. Infect.Drug Resist. 6, 215-223 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 322.3 |
| 分子式 | C10H11N4O5S • Na |
| CAS号 | 89785-84-2 |
| 稳定性 | ≥ 2 years |
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