2-deoxy-2-fluoro L-Fucose
货号：
17171-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 17171-500ug |
| 描述 | Fucose (Item No. 16479) is a deoxyhexose that is present in many organisms. Fucose-containing glycans, generated by fucosyltransferase using GDP-fucose, have roles in cell signaling, cell-cell interactions, and blood properties.1 2-deoxy-2-fluoro L-Fucose is a fluorinated fucose analog. It can be metabolized inside the cell to a substrate-based inhibitor of fucosyltransferases.2 Alternatively, it can be converted in vitro to GDP-2-deoxy-2-fluoro L-fucose, a competitive inhibitor of α1,3-fucosyltransferase V (Ki = 4.2 µM).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Becker, D.J., and Lowe, J.B. Fucose: biosynthesis and biological function in mammals. Glycobiology 13(7), 41R-53R (2003).
2.Rillahan, C.D.,Antonopoulos, A.,Lefort, C.T., et al. Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome. Nature Chemical Biology 8(7), 661-668 (2012).
3.Wong, C.H., and Hayashi, T. Process for preparing nucleotide inhibitors of glycosyltransferases. 763,227, (1998).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 166.1 |
| 分子式 | C6H11FO4 |
| CAS号 | 70763-62-1 |
| 稳定性 | ≥ 2 years |
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