| 货号 | 17162-1mg |
| 描述 | 4-Aminomethyl-4,5,8-trimethylpsoralen is a bifunctional photoreactive agent for crosslinking nucleic acids.1,2 In the dark, it intercalates into double-stranded regions in DNA or RNA. Upon long wavelength UV irradiation (e.g., 365 nm), 4-aminomethyl-4,5,8-trimethylpsoralen first forms a covalent monoadduct with a pyrimidine base, followed by covalently linking with an adjacent pyrimidine on the opposite strand.1,2 Short wavelength UV irradiation (e.g., 254 nm) reverses this reaction. 4-Aminomethyl-4,5,8-trimethylpsoralen has a high binding affinity for RNA and has been used to study different types of RNA from diverse organisms, including viruses.3,4,5 |
| 别名 | 4-Aminomethyltrioxsalen; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Liarakos, C.D.,Reinhart, G.,Kopper, R.A., et al. Characterization of the effects on ovalbumin mRNA of aminomethyl-trimethylpsoralen photoreaction with hen oviduct mRNA. Nucleic Acids Research 15(20), 8417-8438 (1987). 2.Garrett-Wheeler, E.,Lockard, R.E., and Kumar, A. Mapping of psoralen cross-linked nucleotides in RNA. Nucleic Acids Research 12(7), 3405-3423 (1984). 3.Hearst, J.E., and Thiry, L. The photoinactivation of an RNA animal virus, vesicular stomatitis virus, with the aid of newly synthesized psoralen derivatives. Nucleic Acids Research 4(5), 1339-1347 (1977). 4.Hui, C.F., and Cantor, C.R. Mapping the location of psoralen crosslinks on RNA by mung bean nuclease sensitivity of RNA-DNA hybrids. Proceedings of the National Academy of Sciences of the United States of America 82(5), 1381-1385 (1985). 5.Raviprakash, K.,Sun, P.,Raviv, Y., et al. Dengue virus photo-inactivated in presence of 1,5-iodonaphthylazide (INA) or AMT, a psoralen compound (4-aminomethyl-trioxsalen) is highly immunogenic in mice. Hum.Vaccin.Immunother. 9(11), 2336-2341 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 257.3 |
| 分子式 | C15H15NO3 |
| CAS号 | 64358-50-5 |
| 稳定性 | ≥ 2 years |
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