| 货号 | 17151-1mg |
| 描述 | Proteins can be modified post-translationally by the addition of O-linked N-acetylglucosamine (O-GlcNAc). Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT) is a β-N-acetylglucosaminidase that removes GlcNAc from O-glycosylated proteins. PUGNAc is a (phenylcarbamoyl)oxime analog of GlcNAc that reversibly inhibits NCOAT (Ki = 40-110 nM).1,2 It also less potently inhibits other hexosaminidases and exochitinases.2,3,4 (Z)-PUGNAc is a stereoisomer of PUGNAc that is a more potent inhibitor of NCOAT than the (E) isomer, both in vitro and in cells.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Horsch, M.,Hoesch, L.,Vasella, A., et al. N-Acetylglucosaminono-1,5-lactone oxime and the corresponding (phenylcarbamoyl)oxime. Novel and potent inhibitors of β-N-acetylglucosaminidase. European Journal of Biochemistry 197(3), 815-818 (1991). 2.Dong, D.L.Y., and Hart, G.W. Purification and characterization of an O-GlcNAc selective N-acetyl-β-D-glucosaminidase from rat spleen cytosol. The Journal of Biological Chemisty 269(30), 19321-19330 (1994). 3.Hodge, A.,Gooday, G.W., and Alexander, I.J. Inhibition of chitinolytic activities from tree species and associated fungi. Phytochemistry 41, 77-84 (1996). 4.Macauley, M.S.,Bubb, A.K.,Martinez-Fleites, C., et al. Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. The Journal of Biological Chemisty 283(50), 34687-34695 (2008). 5.Perreira, M.,Kim, E.J.,Thomas, C.J., et al. Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorganic & Medicinal Chemistry 14, 837-846 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 353.3 |
| 分子式 | C15H19N3O7 |
| CAS号 | 132489-69-1 |
| 稳定性 | ≥ 2 years |
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