Tivantinib
货号：
17135-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17135-1mg |
| 描述 | MET is a proto-oncogene that encodes the hepatocyte growth factor receptor c-Met. The receptor has normal roles in morphogenesis, migration, apoptosis, and angiogenesis.1 Dysregulation of c-Met occurs in many types of cancer.1 Tivantinib is a staurosporine (Item No. 81590) derivative that binds to dephosphorylated c-Met kinase, yet its mechanism of action is not known.2 Tivantinib has been tested in clinical studies for its ability to selectively inhibit c-Met.2 However, it can promote mitotic arrest and apoptosis of various human tumor cell lines (EC50s ranging from 60-600 nM) through mechanisms independent of its ability to bind c-Met.2 Tivantinib has been reported to bind directly to the colchicine binding site of tubulin, reducing tubulin polymerization in cells and in mouse xenograft tumors in vivo.3 |
| 别名 | ARQ 197; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mughal, A.,Aslam, H.M.,Sheikh, A., et al. c-Met inhibitors. Infect.Agent.Cancer 8, 13 (2013).
2.Basilico, C.,Pennacchietti, S.,Vigna, E., et al. Tivantinib (ARQ197) displays cytotoxic activity that is independent of its ability to bind MET. Clinical Cancer Research 19(9), 2381-2392 (2013).
3.Aoyama, A.,Katayama, R.,Oh-Hara, T., et al. Tivantinib (ARQ 197) exhibits antitumor activity by directly interacting with tubulin and overcomes ABC transporter-mediated drug resistance. Molecular Cancer Therapeutics 13(12), 2978-2990 (2014).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 369.4 |
| 分子式 | C23H19N3O2 |
| CAS号 | 905854-02-6 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
