BAY 60-6583
货号：
17127-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17127-1mg |
| 描述 | BAY 60-6583 is an adenosine A2B receptor agonist (EC50 = 3 nM for human A2B receptors) that displays selectivity over A1, A2A, and A3 receptors (EC50s = >10 µM).1 It has been used to decrease superoxide production in neutrophils and to study the role of the A2B receptor in regulating inflammation and mediating metabolic homeostasis in a mouse model of type 2 diabetes and obesity.2,3 BAY 60-6583 has also been examined for potential clinical use in disorders of the coronary arteries and atherosclerosis and in ischemia-reperfusion injury.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Baraldi, P.G.,Tabrizi, M.A.,Fruttarolo, F., et al. Recent improvements in the development of A2B adenosine receptor agonists. Purinergic Signal. 5(1), 3-19 (2009).
2.van der Hoeven, D.,Wan, T.C.,Gizewski, E.T., et al. A role for the low-affinity A2B adenosine receptor in regulating superoxide generation by murine neutrophils. Journal of Pharmacology and Experimental Therapeutics 338(3), 1004-1012 (2011).
3.Johnston-Cox, H.,Koupenova, M.,Yang, D., et al. The A2b adenosine receptor modulates glucose homeostasis and obesity. PLoS One 7(7), 1-9 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 379.4 |
| 分子式 | C19H17N5O2S |
| CAS号 | 910487-58-0 |
| 稳定性 | ≥ 2 years |
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