Cu-ATSM
货号：
17122-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17122-1mg |
| 描述 | The metallo-protein Cu/Zn-superoxide dismutase (SOD1) is a ubiquitous enzyme responsible for scavenging superoxide radicals. Mutations in SOD1, which alter its metal binding capacity and can result in protein misfolding and aggregation, have been linked to familial amyotrophic lateral sclerosis (ALS). Cu-ATSM is an orally bioavailable, blood-brain barrier permeable complex that has traditionally been used in cellular imaging experiments to selectively label hypoxic tissue via its susceptibility to reduction by oxygen-depleted mitochondria.1 More recently, Cu-ATSM has been reported to improve locomotor function and survival in a transgenic ALS mouse model by delivering copper specifically to cells in the spinal cords of mice producing misfolded SOD1 proteins.2 Copper chaperone for SOD (CCS) is presumed to utilize the copper from Cu-ATSM to prevent misfolding of the SOD1 protein.2,3 |
| 别名 | copper-ATSM;CuII(atsm); |
性能| 供应商 | Cayman |
| 应用文献 |
1.Vavere, A.L., and Lewis, J.S. Cu-ATSM: A radiopharmaceutical for the PET imaging of hypoxia. Dalton Trans. 43, 4893-4902 (2007).
2.Roberts, B.R.,Lim, N.K.H.,McAllum, E.J., et al. Oral treatment with CuII(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neuroscience 34(23), 8021-8031 (2014).
3.Williams, J.R.,Trias, E.,Beilby, P.R., et al. Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD. Neurobiology of Disease 89, (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 321.9 |
| 分子式 | C8H14CuN6S2 |
| CAS号 | 68341-09-3 |
| 稳定性 | ≥ 2 years |
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