| 货号 | 17102-5mg |
| 描述 | ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. It can be readily esterified with other moieties.1 For example, it can be coupled with therapeutics like nonsteroidal anti-inflammatory drugs, as in the generation of ATB-343 (Item No. 13045).2 ADT-OH has also been linked with a mitochondria-targeting motif to produce AP-39 (Item No. 17100), which selectively increases mitochondrial H2S levels.3 ADT-OH is used both in cells and in animals for comparative studies with derived chimeras.3,4 |
| 别名 | ACS1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kashfi, K., and Olson, K.R. Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras. Biochemical Pharmacology 85(5), 689-703 (2013). 2.Wallace, J.L. Hydrogen sulfide-releasing anti-inflammatory drugs. Trends in Pharamacological Sciences 28(10), 501-505 (2007). 3.Szczesny, B.,Módis, K.,Yanagi, K., et al. AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide: Biology and Chemistry 41, 120-130 (2014). 4.Tomasova, L.,Pavlovicova, M.,Malekova, L., et al. Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels. Nitric Oxide: Biology and Chemistry 46, 131-144 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 226.3 |
| 分子式 | C9H6OS3 |
| CAS号 | 18274-81-2 |
| 稳定性 | ≥ 2 years |
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