AP39
货号：
17100-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17100-1mg |
| 描述 | AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria.1 It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (30-300 nM) dose-dependently increases H2S levels in endothelial cells, predominantly in mitochondrial regions.1 It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an inhibitory effect at 300 nM.1 Under oxidative stress conditions induced by glucose oxidase, AP39 has antioxidant and cytoprotective effects.1 AP39 is effective in vivo, inhibiting voltage-dependent T-type calcium channels and improving hemodynamic parameters in rats.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Szczesny, B.,Módis, K.,Yanagi, K., et al. AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro. Nitric Oxide: Biology and Chemistry 41, 120-130 (2014).
2.Tomasova, L.,Pavlovicova, M.,Malekova, L., et al. Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels. Nitric Oxide: Biology and Chemistry 46, 131-144 (2015).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 641.9 |
| 分子式 | C37H38O2PS3 |
| CAS号 | 1429173-57-8 |
| 稳定性 | ≥ 1 year |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
