SGC707
货号：
17017-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 17017-1mg |
| 描述 | Protein arginine N-methyltransferase 3 (PRMT3, Item No. 11642) is a predominantly cytoplasmic enzyme that is constitutively expressed.1,2 SGC707 is a potent allosteric inhibitor of PRMT3 (IC50 = 50 nM) with >100-fold selectivity over other methyltransferases and other non-epigenetic targets. Developed by the Structural Genomics Consortium (SGC), SGC707 avidly binds PRMT3 (Kd = 50 nM by isothermal titration calorimetry) and inhibits the methylation of histones in cells with an IC50 value below 1 µM. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tang, J.,Gary, J.D.,Clarke, S., et al. PRMT3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation. The Journal of Biological Chemisty 273(27), 16935-16945 (1998).
2.Wolf, S.S. The protein arginine methyltransferase family: An update about function, new perspectives and the physiological role in humans. Cellular and Molecular Life Sciences 66, 2109-2121 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 298.3 |
| 分子式 | C16H18N4O2 |
| CAS号 | 1687736-54-4 |
| 稳定性 | ≥ 2 years |
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