| 货号 | 16987-5mg |
| 描述 | Cryptotanshinone is a natural quinoid diterpene first isolated from Salvia miltiorrhiza roots, which are used in traditional Chinese medicine for a variety of conditions.1 Cryptotanshinone, at 10-20 µM, stimulates AMP-activated protein kinase in C2C12 myotubes and activates p38 MAPK in DU145 cells.2,3 It inhibits the protein tyrosine phosphatase SHP2 in vitro(IC50 = 22.5 µM) and, at 4-8 µM, blocks phosphorylation of STAT3 in MC-3 cells.4,5 Cryptotanshinone has a variety of anti-cancer actions, including inhibition of cell proliferation, induction of apoptosis, and reduction in angiogenesis.1,5,6 However, it is poorly absorbed and has low bioavailability in vivo.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chen, W.,Lu, Y.,Chen, G., et al. Molecular evidence of cryptotanshinone for treatment and prevention of human cancer. Anticancer Agents Med.Chem. 13(7), 979-987 (2013). 2.Kim, E.J.,Jung, S.N.,Son, K.H., et al. Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase. Molecular Pharmacology 72(1), 62-72 (2007). 3.Chen, W.,Liu, L.,Luo, Y., et al. Cryptotanshinone activates p38/JNK and inhibits Erk1/2 leading to caspase-independent cell death in tumor cells. Cancer Prevention Research 5(5), 778-787 (2012). 4.Liu, W.,Yu, B.,Xu, G., et al. Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11). Journal of Medicinal Chemistry 56(18), 7212-7221 (2013). 5.Yu, H.J.,Park, C.,Kim, S.J., et al. Signal transducer and activators of transcription 3 regulates cryptotanshinone-induced apoptosis in human mucoepidermoid carcinoma cells. Pharmacogn.Mag. 10(Suppl 3), S622-S629 (2014). 6.Zhang, Y.,Jiang, P.,Ye, M., et al. Tanshinones: Sources, pharmacokinetics and anti-cancer activities. International Journal of Molecular Sciences 13(10), 13621-13666 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 296.4 |
| 分子式 | C19H20O3 |
| CAS号 | 35825-57-1 |
| 稳定性 | ≥ 2 years |
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