RU-SKI 43 (hydrochloride)
货号：
16972-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16972-1mg |
| 描述 | Hedgehog acyltransferase (Hhat) is an N-palmitoyltransferase that acylates Sonic hedgehog (Shh), which is critical for signaling through Shh. RU-SKI 43 is an inhibitor of Hhat (IC50 = 0.85 µM).1 It blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a.1 RU-SKI 43 is cell-permeable and inhibits both autocrine and paracrine Shh-induced activation of Gli-mediated transcription.1 In pancreatic cancer cells, RU-SKI 43 reduces both Gli1 activation and proliferation.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Petrova, E.,Rios-Esteves, J.,Ourfelli, O., et al. Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling. Nature Chemical Biology 9(4), 247-249 (2013).
2.Petrova, E.,Matevossian, A., and Resh, M.D. Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma. Oncogene 34, 263-268 (2015).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 423 |
| 分子式 | C22H30N2O2S • HCl |
| CAS号 | 1782573-67-4 |
| 稳定性 | ≥ 2 years |
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