| 货号 | 16948-1g |
| 描述 | L-Carnitine is an essential amino acid that has diverse roles in metabolism, most notably facilitating the transport of long-chain fatty acids into the mitochondrial matrix for β-oxidation.1,2,3 It is also important for the maintenance of coenzyme A (CoA; Item No. 16147) stores. L-Acetylcarnitine is an acetylated form of L-carnitine that is catabolized by plasma esterases into carnitine. L-Acetylcarnitine facilitates the uptake of acetyl CoA into mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis. L-Acetylcarnitine has been explored for use in targeting cardiovascular pathologies, and, as an acetylcholine mimic, it has also been examined for neuroprotective benefits.4,5 |
| 别名 | Acetyl-L-Carnitine;ALCAR; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vaz, F.M., and Wanders, R.J.A. Carnitine biosynthesis in mammals. Biochem. J. 361(Pt 3), 417-429 (2002). 2.Fu, L.,Huang, M., and Chen, S. Primary carnitine deficiency and cardiomyopathy. Korean. Circ. J. 43(12), 785-792 (2013). 3.Stieger, B.,ONeill, B., and Krähenbühl, S. Characterization of L-carnitine transport by rat kidney brush-border-membrane vesicles. Biochemistry Journal 309(Pt 2), 643-647 (1995). 4.Mingorance, C.,Rodríguez-Rodríguez, R.,Justo, M.L., et al. Critical update for the clinical use of L-carnitine analogs in cardiometabolic disorders. Vascular Health and Risk Management 7, 169-176 (2011). 5.. Acetyl-L-carnitine Monograph. Altern.Med.Rev. 15(1), 76-83 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 240.7 |
| 分子式 | C9H18NO4 • HCl |
| 稳定性 | ≥ 2 years |
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