| 货号 | 16946-10mg |
| 描述 | 7,8-Dihydroxyflavone (7,8-DHF) is a monophenolic flavone with diverse effects. It acts as an agonist of the neurotrophic tyrosine kinase receptor TrkB (Kd = 320 nM), protecting neurons that express TrkB from apoptosis.1 7,8-DHF is neuroprotective in an animal model of Parkinson’s disease.1 It supports emotional learning in mice and reverses memory deficits in a mouse model of Alzheimer’s disease.2,3 It also improves motor function and extends survival in an animal model of Huntington’s disease.4 7,8-DHF inhibits the cytochrome P450 aromatase (IC50 = 10 µM) and, in this way, alters estrogen metabolism.5 It also has antioxidant action that increases intracellular glutathione synthesis and scavenges reactive oxygen species.6 |
| 别名 | 7,8-DHF; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jang, S.W.,Liu, X.,Yepes, M., et al. A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proceedings of the National Academy of Sciences of the United States of America 107(6), 2687-2692 (2010). 2.Andero, R.,Heldt, S.A.,Ye, K., et al. Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. Am.J.Psychiatry 168(2), 163-172 (2011). 3.Devi, L., and Ohno, M. 7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer’s disease. Neuropsychopharmacology 37(2), 434-444 (2012). 4.Jiang, M.,Peng, Q.,Liu, X., et al. Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington’s disease. Human Molecular Genetics 22(12), 2462-2470 (2013). 5.Kao, Y.C.,Zhou, C.,Sherman, M., et al. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. Environmental Health Perspectives 106(2), 85-92 (1998). 6.Choi, J.Y.,Kang, J.T.,Park, S.J., et al. Effect of 7,8-dihydroxyflavone as an antioxidant on in vitro maturation of oocytes and development of parthenogenetic embryos in pigs. Journal of Reproduction and Development 59(5), 450-456 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 254.2 |
| 分子式 | C15H10O4 |
| CAS号 | 38183-03-8 |
| 稳定性 | ≥ 2 years |
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