Glycochenodeoxycholic Acid (sodium salt)
货号：
16942-25mg 基本售价：
350.0 元 规格：
25 mg
产品信息
概述| 货号 | 16942-25mg |
| 描述 | Glycochenodeoxycholic acid (GCDCA) is a bile salt formed in the liver by conjugation of chenodeoxycholate with glycine.1 It acts as a biosurfactant to solubilize lipids for absorption and is itself absorbed. GCDCA functions as a choleretic, increasing the volume of bile secreted from the liver, and a cholagogue, promoting the discharge of bile from the digestive system. GCDCA has been used to demonstrate a role for bile acids in promoting colorectal carcinogenesis and to inhibit calcium hydroxyapatite precipitation to study the pathogenesis of black pigment gallstones.2,3 |
| 别名 | GCDCA;NSC 681056; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Barnes, S.,Burhol, P.G.,Zander, R., et al. Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters. Journal of Lipid Research 20(8), 952-959 (1979).
2.Ishizuka, S.,Shiwaku, M.,Hagio, M., et al. Glycochenodeoxycholic acid promotes proliferation of intestinal epithelia via reduction of cyclic AMP and increase in H2AX phosphorylation after exposure to γ-rays. Biomed.Res. 33(3), 159-165 (2012).
3.Qiu, S.M.,Wen, G.,Hirakawa, N., et al. Glycochenodeoxycholic acid inhibits calcium phosphate precipitation in vitro by preventing the transformation of amorphous calcium phosphate to calcium hydroxyapatite. Journal of Clinical Investigation 88(4), 1265-1271 (1991).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 471.6 |
| 分子式 | C26H42NO5 • Na |
| CAS号 | 16564-43-5 |
| 稳定性 | ≥ 2 years |
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