| 货号 | 16939-1g |
| 描述 | Histamine H2 receptors mediate gastric acid secretion by coupling to Gαs proteins and increasing cAMP formation.1 Ranitidine is an antihistamine that antagonizes the histamine H2 receptor (pKi = 7.1) in gastric cells, which leads to a decrease in gastric acid secretion and a reduction of hydrogen ion concentration.2,3 Ranitidine inhibits intracellular cAMP production with an IC50 value of 1 µM.4 Its gastroprotective activity has been exploited for the treatment of various gastric acid disorders.5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bakker, R.A.,Timmerman, H., and Leurs, R. Histamine receptors: Specific ligands, receptor biochemistry, and signal transduction. Clin.Allergy Immunol. 17, 27-64 (2002). 2.Daly, M.J.,Humphray, J.M., and Stables, R. Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. British Journal of Pharmacology 72(1), 49-54 (1981). 3.Thurmond, R.L.,Gelfand, E.W., and Dunford, P.J. The role of histamine H1 and H4 receptors in allergic inflammation: The search for new antihistamines. Nature Reviews.Drug Discovery 7, 41-53 (2008). 4.Kim, D.C.,Choi, S.-Y.S.,Kim, S.H., et al. Isoliquiritigenin selectivity inhibits H2 histamine receptor signaling. Molecular Pharmacology 70(2), 493-500 (2006). 5.Tuskey, A., and Peura, D. The use of H2 antagonists in treating and preventing NSAID-induced mucosal damage. Arthritis Research & Therapy 15(Suppl 3), 1-7 (2013). 6.Feldman, M., and Burton, M.E. Histamine2-receptor antagonists. Standard therapy for acid-peptic diseases. (First of two parts). New England Journal of Medicine 323(24), 1672-1680 (1990). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 350.9 |
| 分子式 | C13H22N4O3S • HCl |
| CAS号 | 66357-59-3 |
| 稳定性 | ≥ 2 years |
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