| 货号 | 16938-10mg |
| 描述 | Tomatidine is a steroidal alkaloid found in skins and leaves of tomatoes. It has been shown to suppress NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of iNOS and COX-2.1 It is a reported functional inhibitor of acid sphingomyelinase.2 Tomatidine also has antibacterial properties, blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis more potently than normal strains (MICs = 0.12 and >16 µg/ml, respectively).3 It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice.4 Tomatidine has also been used as a negative control for cyclopamine (Item No. 11321) in studies involving signaling mediated by the hedgehog pathway.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chiu, F.L., and Lin, J.K. Tomatidine inhibits iNOS and COX-2 through suppression of NF-κB and JNK pathways in LPS-stimulated mouse macrophages. FEBS Letters 582(16), 2407-2412 (2008). 2.Kornhuber, J.,Muehlbacher, M.,Trapp, S., et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One 6(8), 1-13 (2011). 3.Mitchell, G.,Gattuso, M.,Grondin, G., et al. Tomatidine inhibits replication of Staphylococcus aureus small-colony variants in cystic fibrosis airway epithelial cells. Antimicrobial Agents and Chemotherapy 55(5), 1937-1945 (2011). 4.Dyle, M.C.,Ebert, S.M.,Cook, D.P., et al. Systems-based discovery of tomatidine as a natural small molecule inhibitor of skeletal muscle atrophy. The Journal of Biological Chemisty 289(21), 14913-14924 (2014). 5.Zhao, C.,Chen, A.,Jamieson, C.H., et al. Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature 458(7239), 776-779 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 452.1 |
| 分子式 | C27H45NO2 • HCl |
| CAS号 | 6192-62-7 |
| 稳定性 | ≥ 2 years |
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