RGFP966
货号：
16917-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16917-1mg |
| 描述 | HDAC3 is highly expressed in brain, and its activity has been associated with negative regulation of learning and memory processes. RGFP966 is a selective inhibitor of HDAC3 (IC50 = 0.08 µM) that does not affect other HDACs at concentrations up to 15 µM.1 At 10 mg/kg, RGFP966 can facilitate the extinction of cocaine-seeking behavior and enhance long-term object memory acquisition/consolidation in mice.1 At 10 µM, RGFP966 can also induce apoptosis of cutaneous T cell lymphoma cells by disrupting their DNA replication activity.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Malvaez, M.,McQuown, S.C.,Rogge, G.A., et al. HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proceedings of the National Academy of Sciences of the United States of America 110(7), 2647-2652 (2013).
2.Wells, C.E.,Bhaskara, S.,Stengel, K.R., et al. Inhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphoma. PLoS One 8(7), 1-13 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 362.4 |
| 分子式 | C21H19FN4O |
| CAS号 | 1357389-11-7 |
| 稳定性 | ≥ 2 years |
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