NSC 632839
货号：
16893-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16893-1mg |
| 描述 | Protein ubiquitination is a dynamic process that can be reversed by deubiquitinating enzymes (DUBs) that remove ubiquitin from proteins, sparing them from degradation by the proteasome. The DUBs have been divided into various groups, the largest being the ubiquitin-specific proteases (USPs). NSC 632839 inhibits USP2 and USP7 as well as the ubiquitin-like SUMO peptidase SENP2 with EC50 values of 45, 37, and 9.8 µM, respectively.1 It is reported to inhibit apoptosis through a Bcl-2-dependent and apoptosome-independent pathway of caspase activation (IC50 = 15.7 µM in cells sensitized by E1A, an adenoviral oncogene).2 |
| 别名 | F6;Ubiquitin Isopeptidase Inhibitor II; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nicholson, B.,Leach, C.A.,Goldenberg, S.J., et al. Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities. Protein Science 17(6), 1035-1043 (2008).
2.Aleo, E.,Henderson, C.J.,Fontanini, A., et al. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Research 66(18), 9235-9244 (2006).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 339.9 |
| 分子式 | C21H21NO • HCl |
| CAS号 | 157654-67-6 |
| 稳定性 | ≥ 2 years |
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