| 货号 | 16889-25mg |
| 描述 | DL-α-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase that suppresses polyamine biosynthesis.1 DFMO displays antiangiogenic and cytostatic effects in tumor cells but must be used in combination with other chemotherapeutic agents to negate compensatory increases in polyamine content through alternate synthesis pathways.1,2,3,4 Through inhibition of polyamine synthesis, DFMO also demonstrates antiparasitic activity in a model of C. parvuminfection.5 |
| 别名 | DFMO;Eflornithine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Wallace, H.M.,Fraser, A.V., and Hughes, A. A perspective of polyamine metabolism. Biochemistry Journal 376(Pt 1), 1-14 (2003). 2.Takigawa, M.,Enomoto, M.,Nishida, Y., et al. Tumor angiogenesis and polyamines: α-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro. Cancer Research 50(13), 4131-4138 (2014). 3.Marton, L.J.,Levin, V.A.,Hervatin, S.J., et al. Potentiation of the antitumor therapeutic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea by α-difluoromethylornithine, an ornithine decarboxylase inhibitor. Cancer Research 41(11 Pt 1), 4426-4431 (1981). 4.Hayes, C.S.,Burns, M.R., and Gilmour, S.K. Polyamine blockade promotes antitumor immunity. Oncoimmunology 3(1), e27360-27361-e27360-27363 (2014). 5.Yarlett, N.,Waters, W.R.,Harp, J.A., et al. Activities of DL-α-difluoromethylarginine and polyamine analogues against Cryptosporidium parvum infection in a T-cell receptor α-deficient mouse model. Antimicrobial Agents and Chemotherapy 51(4), 1234-1239 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 236.6 |
| 分子式 | C6H12F2N2O2 • HCl [H2O] |
| CAS号 | 96020-91-6 |
| 稳定性 | ≥ 2 years |
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