R-7050
货号：
16870-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16870-1mg |
| 描述 | R-7050 is a cell-permeable antagonist of signaling through the TNF-α receptor complex (EC50 = 0.631 µM).1 It blocks TNF-α-induced binding of TNF-α receptor I with TNF-α receptor-associated death domain protein and receptor interacting protein 1, which, in turn, prevents internalization of the receptor complex.1 R-7050 is 2.3-fold more selective for TNF-α-mediated signaling than for that driven by IL-1β.1 It has been used to investigate the role of TNF-α in neurovascular injury and mycotoxin-induced anorexia.2,3 |
| 别名 | TNF-α Antagonist III; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gururaja, T.L.,Yung, S.,Ding, R., et al. A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1. Chemistry & Biology 14(10), 1105-1118 (2007).
2.King, M.D.,Alleyne, C.H., Jr., and Dhandapani, K.M. TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice. Neuroscience Letters 542, 92-93 (2013).
3.Wu, W., and Zhang, H. Role of tumor necrosis factor-α and interleukin-1β in anorexia induction following oral exposure to the trichothecene deoxynivalenol (vomitoxin) in the mouse. Journal of Toxicological Sciences 39(6), 875-886 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 380.8 |
| 分子式 | C16H8ClF3N4S |
| CAS号 | 303997-35-5 |
| 稳定性 | ≥ 2 years |
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