| 货号 | 16789-1g |
| 描述 | Bacterial DNA gyrase is a heterodimeric type II topoisomerase that negatively supercoils circular double-stranded DNA.1,2 Oxolinic acid is a quinolone antibiotic that inhibits bacterial DNA gyrase, but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 µg/ml.1,3,4 Oxolinic acid also blocks neuronal uptake of dopamine in mammals (IC50 = 4.3 µM), leading to an increase in locomotor activity.5 |
| 别名 | NSC 110364;Urinox; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Drlica, K., and Zhao, X. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiology and Molecular Biology Reviews 61(3), 377-392 (1997). 2.Collin, F.,Karkare, S., and Maxwell, A. Exploiting bacterial DNA gyrase as a drug target: Current state and perspectives. Appl. Microbiol. Biotechnol. 92(3), 479-497 (2011). 3.Hays, J.B., and Boehmer, S. Antagonists of DNA gyrase inhibit repair and recombination of UV-irradiated phage λ. Proceedings of the National Academy of Sciences of the United States of America 75(9), 4125-4129 (1978). 4.Engle, E.C.,Manes, S.H., and Drlica, K. Differential effects of antibiotics inhibiting gyrase. Journal of Bacteriology 149(1), 92-98 (1982). 5.García de Mateos-Verchere, J.,Vaugeois, J.M.,Naudin, B., et al. Behavioural and neurochemical evidence that the antimicrobial agent oxolinic acid is a dopamine uptake inhibitor. European Neuropsychopharmacology 8(4), 255-259 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 261.2 |
| 分子式 | C13H11NO5 |
| CAS号 | 14698-29-4 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |