| 货号 | 16727-5mg |
| 描述 | Tideglusib is a thiadiazolidinone that prevents inflammation and neurodegeneration when injected into rat hippocampus concurrently with kainic acid, a compound that causes excitotoxicity.1 Tideglusib-induced neuroprotection, in this model, is attenuated by the PPARγ antagonist GW9662 (Item No. 70785).1 Interestingly, tideglusib also irreversibly inhibits glycogen synthase kinase-3β (GSK3β) with an IC50 value of 5 nM when used with a one hour preincubation, increasing to 0.1-1 µM without preincubation.2,3 Several GSK3 inhibitors, including tideglusib, promote hippocampal neurogenesis both in vitroandin vivo, suggesting suitability in Alzheimer’s therapy.3,4 |
| 别名 | NP031112; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Luna-Medina, R.,Cortes-Canteli, M.,Sanchez-Galiano, S., et al. NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: Potential therapeutic role in brain disorders. Journal of Neuroscience 27(21), 5766-5776 (2007). 2.Domínguez, J.M.,Fuertes, A.,Orozco, L., et al. Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib. The Journal of Biological Chemisty 287(2), 893-904 (2012). 3.Morales-Garcia, J.A.,Luna-Medina, R.,Alonso-Gil, S., et al. Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo. ACS Chem.Neurosci. 3(11), 963-971 (2012). 4.Martinez, A.,Gil, C. and Perez, D.I. Glycogen synthase kinase 3 inhibitors in the next horizon for Alzheimer’s disease treatment. Int.J.Alzheimers Dis. 2011, 1-8 (2011). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 334.4 |
| 分子式 | C19H14N2O2S |
| CAS号 | 865854-05-3 |
| 稳定性 | ≥ 2 years |
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