| 货号 | 16723-500ug |
| 描述 | Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is cleaved by serine proteases, resulting in self-activation of the receptor by a tethered ligand.1,2 The ligand corresponds to residues 39-44 (SLIGRL in mouse PAR-2).1,2 SLIGRL-NH2 is a recombinant peptide that activates PAR2 (EC50 = ~5 µM), without requiring receptor cleavage.1,2 This peptide does not activate PAR1. Through its effects on PAR2, SLIGRL-NH2 stimulates gastric and intestinal smooth muscle contraction and induces thermal hyperalgesia in mice.3,4SLIGRL-NH2 is used to explore signaling through PAR2 in cells and in animals.5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Nystedt, S.,Emilsson, K.,Wahlestedt, C., et al. Molecular cloning of a potential proteinase activated receptor. Proceedings of the National Academy of Sciences of the United States of America 97(20), 9208-9212 (1994). 2.Nystedt, S.,Larsson, A.K.,Aberg, H., et al. The mouse proteinase-activated receptor-2 cDNA and gene. Molecular cloning and functional expression. The Journal of Biological Chemisty 270(11), 5950-5955 (1995). 3.Kawabata, A.,Kuroda, R.,Nagata, N., et al. In vivo evidence that protease-activated receptors 1 and 2 modulate gastrointestinal transit in the mouse. British Journal of Pharmacology 133(8), 1213-1218 (2001). 4.Liu, Q.,Weng, H.J.,Patel, K.N., et al. The distinct roles of two GPCRs, MrgprC11 and PAR2, in itch and hyperalgesia. Science Signaling 4(181), 1-6 (2011). 5.Sriwai, W.,Mahavadi, S.,Al-Shboul, O., et al. Distinctive G protein-dependent signaling by protease-activated receptor 2 (PAR2) in smooth muscle: Feedback inhibition of RhoA by cAMP-independent PKA. PLoS One 8(6), 1-12 (2013). 6.Elmariah, S.B.,Reddy, V.B. and Lerner, E.A. Cathepsin S signals via PAR2 and generates a novel tethered ligand receptor agonist. PLoS One 9(6), 1-9 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 656.8 |
| 分子式 | C29H56N10O7 |
| CAS号 | 171436-38-7 |
| 稳定性 | ≥ 2 years |
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