| 货号 | 16672-5mg |
| 描述 | Rhodamine 123 is a membrane-permeable cationic dye that is readily accumulated within living cells. It is a substrate for the efflux pump P-glycoprotein (P-gp; also known as multidrug resistance protein 1 and ABCB1) and is rapidly exported from cells with functional P-gp.1,2 As P-gp is expressed on a population of stem cells known as the side population, rhodamine 123 is used to detect this group of stem cells.2,3 Rhodamine 123 also accumulates within mitochondria and can be used to both localize mitochondria and study their properties.4,5 Rhodamine 123 has natural absorption maxima at 501 and 507 nm and an emission maximum at 529 nm but is commonly evaluated using filters providing excitation at 488 nm and emission at 550 nm.6 |
| 别名 | R-22420;R-302;RH123; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hegmann, E.J.,Bauer, H.C. and Kerbel, R.S. Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells. Cancer Research 52(24), 6969-6975 (1992). 2.Huls, M.,Russel, F.G.M. and Masereeuw, R. The role of ATP binding cassette transporters in tissue defense and organ regeneration. Journal of Pharmacology and Experimental Therapeutics 328(1), 3-9 (2009). 3.Challen, G.A. and Little, M.H. A side order of stem cells: The SP phenotype. Stem Cells 24(1), 3-12 (2006). 4.Foster, K.A.,Galeffi, F.,Gerich, F.J., et al. Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration. Progress in Neurobiology 79(3), 136-171 (2006). 5.Kurtoglu, M. and Lampidis, T.J. From delocalized lipophilic cations to hypoxia: Blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors. Mol.Nutr.Food Res. 53(1), 68-75 (2009). 6.Sabnis, R.W. Handbook of biological dyes and stains: Synthesis and industrial applications. (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 380.8 |
| 分子式 | C21H17N2O3 • Cl |
| CAS号 | 62669-70-9 |
| 稳定性 | ≥ 2 years |
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