GPR120 Compound A
货号：
16624-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16624-1mg |
| 描述 | GPR120 (free fatty acid receptor 4/FFAR4) is a G protein-coupled receptor expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids. It has been linked to the ability of fatty acids to produce anti-inflammatory effects and to acutely potentiate insulin secretion. GPR120 compound A is an orally available, high-affinity agonist of GPR120 (EC50 = ~0.35 µM) that demonstrates potent selectivity over another lipid-sensing G-protein, GPR40 (FFAR1).1 This compound exerts anti-inflammatory effects on macrophages in vitro and improves glucose tolerance, decreases hyperinsulinemia, increases insulin sensitivity, and decreases hepatic steatosis when included at 30 mg/kg body weight in a high-fat diet fed to obese mice.1 |
| 别名 | GPR120 cpdA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Oh da, Y.,Walenta, E.,Akiyama, T.E., et al. A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. Nature Medicine 20(8), 942-947 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 405.8 |
| 分子式 | C19H23ClF3NO3 |
| CAS号 | 1599477-75-4 |
| 稳定性 | ≥ 2 years |
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