| 货号 | 16621-1mg |
| 描述 | MitoTEMPO is a mitochondria-targeted superoxide dismutase mimetic that possesses superoxide and alkyl radical scavenging properties.1 This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria.1 Mitochondrial targeting of superoxide scavenging via mitoTEMPO has been examined for potential therapeutic benefit to a variety of mitochondrondrial dysfunctions arising from excessive reactive oxygen species.2,3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dikalov, S. Cross talk between mitochondria and NADPH oxidases. Free Radical Biology & Medicine 51(7), 1289-1301 (2011). 2.Liang, H.L.,Arsenault, J.,Mortensen, J., et al. Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells. Apoptosis 14(10), 1176-1189 (2009). 3.Dikalova, A.E.,Bikineyeva, A.T.,Budzyn, K., et al. Therapeutic targeting of mitochondrial superoxide in hypertension. Circulation Research 107(1), 106-116 (2010). 4.Liang, H.L.,Sedlic, F.,Bosnjak, Z., et al. SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery. Free Radical Biology & Medicine 49(10), 1550-1560 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 528 |
| 分子式 | C29H35N2O2P • Cl [H2O] |
| CAS号 | 1569257-94-8 |
| 稳定性 | ≥ 2 years |
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