| 货号 | 16608-1mg |
| 描述 | BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase (IC50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase.1,2,3 It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT.2,4 Through its effects on telomerase, BIBR 1532 induces senescence or apoptosis in cancer cells.1,5 Apoptosis in triple negative breast cancer cells induced by BIBR 1532 is potentiated by glucose restriction.5 |
| 别名 | Telomerase Inhibitor X; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Damm, K.,Hemmann, U.,Garin-Chesa, P., et al. A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO Journal 20(24), 6958-6968 (2014). 2.Pascolo, E.,Wenz, C.,Lingner, J., et al. Mechanism of human telomerase inhibition by BIBR1532, a synthetic, non-nucleosidic drug candidate. The Journal of Biological Chemisty 277(18), 15566-15572 (2002). 3.Piotrowska, K.,Kleideiter, E.,Mürdter, T.E., et al. Optimization of the TRAP assay to evaluate specificity of telomerase inhibitors. Laboratory Investigation 85(12), 1565-1569 (2005). 4.Phatak, P. and Burger, A.M. Telomerase and its potential for therapeutic intervention. British Journal of Pharmacology 152(7), 1003-1011 (2007). 5.Wardi, L.,Alaaeddine, N.,Raad, I., et al. Glucose restriction decreases telomerase activity and enhances its inhibitor response on breast cancer cells: Possible extra-telomerase role of BIBR 1532. Cancer Cell Int. 14, 1-14 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 331.4 |
| 分子式 | C21H17NO3 |
| CAS号 | 321674-73-1 |
| 稳定性 | ≥ 2 years |
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