| 货号 | 16606-1g |
| 描述 | Muscarinic receptors are G protein-coupled acetylcholine receptors that play diverse roles. Five subtypes (M1-5) have been identified, which preferentially couple to various effector systems based on their G protein interaction.1,2 Tropicamide is a muscarinic acetylcholine receptor (mAChR) antagonist (pKi = 7.2 in chicken heart) that displays 3-fold selectivity for M4.1,3,4 When applied as eye drops, it produces temporary mydriasis (pupil dilation; EC50 = 6 µg/ml) and cycloplegia (ciliary muscle paralysis; EC50 = 25 µg/ml).5 Tropicamide has been used to probe mAChR activity in a mouse model of fragile X syndrome.6 |
| 别名 | Ro 1-7683; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lazareno, S.,Buckley, N.J. and Roberts, F.F. Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cell. Molecular Pharmacology 38(6), 805-815 (1990). 2.Liao, C.F.,Themmen, A.P.N.,Joho, R., et al. Molecular cloning and expression of a fifth muscarinic acetylcholine receptor. The Journal of Biological Chemisty 264(13), 7328-7337 (1989). 3.Lazareno, S. and Birdsall, N.J.M. Pharmacological characterization of acetylcholine-stimulated [35S]-GTPγS binding mediated by human muscarinic m1-m4 receptors: Antagonist studies. British Journal of Pharmacology 109(4), 1120-1127 (1993). 4.Hernández, M.,Símonsen, U.,Prieto, D., et al. Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter. British Journal of Pharmacology 110(4), 1413-1420 (1993). 5.Smith, S.E. Dose-response relationships in tropicamide-induced mydriasis and cycloplegia. British Journal of Clinical Pharmacology 1(1), 37-40 (1974). 6.Veeraragavan, S.,Bui, N.,Perkins, J.R., et al. The modulation of fragile X behaviors by the muscarinic M4 antagonist, tropicamide. Behav.Neurosci. 125(5), 783-790 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 284.4 |
| 分子式 | C17H20N2O2 |
| CAS号 | 1508-75-4 |
| 稳定性 | ≥ 2 years |
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