| 货号 | 16604-100mg |
| 描述 | Nicotinamide is a precursor of NAD (Item No. 16077) and NADP (Item No. 10004675), which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; Item No. 15138).1 It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability.2,3 Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.4,5 |
| 别名 | N1-Methylnicotinamide chloride;Nicotinamide methochloride;Trigonellamide chloride; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Alston, T.A. and Abeles, R.H. Substrate specificity of nicotinamide methyltransferase isolated from porcine liver. Archives of Biochemistry and Biophysics 260(2), 601-608 (1988). 2.Chlopicki, S.,Swies, J.,Mogielnicki, A., et al. 1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway. British Journal of Pharmacology 152(2), 230-239 (2007). 3.Domagala, T.B.,Szeffler, A.,Dobrucki, L.W., et al. Nitric oxide production and endothelium-dependent vasorelaxation ameliorated by N1-methylnicotinamide in human blood vessels. Hypertension 59(4), 825-832 (2012). 4.Ulanovskaya, O.A.,Zuhl, A.M. and Cravatt, B.F. NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nature Chemical Biology 9(5), 300-306 (2013). 5.Shlomi, T. and Rabinowitz, J.D. Cancer mistunes methylation. Nature Chemical Biology 9(5), 293-294 (2013). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 172.6 |
| 分子式 | C7H9N2O • Cl |
| CAS号 | 1005-24-9 |
| 稳定性 | ≥ 2 years |
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