| 货号 | 16568-1mg |
| 描述 | Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects.1,2trans-AUCB is a very potent inhibitor of sEH (IC50 = 0.5 nM).3 It displays high oral bioavailability for doses ranging from 0.01 to 1 mg/kg.4,5 Dual inhibition of COX-2 and sEH, by celecoxib (Item No. 10008672) and trans-AUCB, suppresses tumor angiogenesis, inhibiting tumor growth and metastasis in a Lewis lung carcinoma model in mice.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Schmelzer, K.R.,Kubala, L.,Newman, J.W., et al. Soluble epoxide hydrolase is a therapeutic target for acute inflammation. Proceedings of the National Academy of Sciences of the United States of America 102(28), 9772-9777 (2005). 2.Yu, Z.,Xu, F.,Huse, L.M., et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circulation Research 87, 992-998 (2000). 3.Hwang, S.H.,Wagner, K.M.,Morisseau, C., et al. Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase. Journal of Medicinal Chemistry 54(8), 3037-3050 (2011). 4.Tsai, H.J.,Hwang, S.H.,Morisseau, C., et al. Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs. European Journal of Pharmaceutical Sciences 40(3), 222-238 (2010). 5.Imig, J.D. and Hammock, B.D. Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases. Nature Reviews.Drug Discovery 8, 794-805 (2009). 6.Zhang, G.,Panigrahy, D.,Hwang, S.H., et al. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis. Proceedings of the National Academy of Sciences of the United States of America 111(30), 11127-11132 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 412.5 |
| 分子式 | C24H32N2O4 |
| CAS号 | 885012-33-9 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |