| 货号 | 16537-1mg |
| 描述 | 2-Oleoyl glycerol (2-OG) is a natural monoacylglycerol with an 18:1 oleoyl group at the sn-2 position of glycerol. 2-OG, like 2-arachidonoyl glycerol (2-AG; Item No. 62160), is metabolized by monoacylglycerol lipase, but, unlike 2-AG, it is not metabolized by cyclooxygenases or lipoxygenases.1,2,3 2-OG is an agonist of GPR119 (EC50 = 2.5 µM), stimulating the release of glucagon-like peptide-1 from intestinal L-cells.4 |
| 别名 | 2-Monoolein;2-OG; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brengdahl, J. and Fowler, C.J. A novel assay for monoacylglycerol hydrolysis suitable for high-throughput screening. Analytical Biochemistry 359, 40-44 (2006). 2.Ghafouri, N.,Tiger, G.,Razdan, R.K., et al. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. British Journal of Pharmacology 143, 774-784 (2004). 3.Woodhams, S.G.,Wong, A.,Barrett, D.A., et al. Spinal administration of the monoacylglycerol lipase inhibitor JZL184 produces robust inhibitory effects on nociceptive processing and the development of central sensitization in the rat. Brit.J.Pharmacol. 167, 1609-1619 (2012). 4.Hansen, K.B.,Rosenkilde, M.M.,Knop, F.K., et al. 2-Oleoyl glycerol is a GRP119 agonist and signals GLP-1 release in humans. Journal of Clinical Endocrinology and Metabolism 96(9), E1409-E1417 (2011). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥98% |
| 计算分子量 | 356.5 |
| 分子式 | C21H40O4 |
| CAS号 | 3443-84-3 |
| 稳定性 | ≥ 1 year |
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