SR 1078
货号：
16503-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 16503-1mg |
| 描述 | Retinoic acid receptor-related orphan receptors α and γ (RORα and RORγ) have been demonstrated to play important roles in the regulation of metabolism, circadian rhythms, immune function, and tumorigenesis. SR 1078 is a selective agonist of RORα and RORγ that stimulates ROR transcriptional activity in HEK293 cell reporter assays at concentrations as low as 2 µM without effect at the related liver X receptors and farnesoid X receptors.1 At 5 µM, SR 1078 has been shown to stabilize p53 and to induce apoptosis in HepG2 cancer cells.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wang, Y.,Kumar, N.,Nuhant, P., et al. Identification of a synthetic agonist for the orphan nuclear receptors RORα and RORγ, SR1078. ACS Chemical Biology 5(11), 1029-1034 (2010).
2.Wang, Y.,Solt, L.A.,Kojetin, D.J., et al. Regulation of p53 stability and apoptosis by a ROR agonist. PLoS One 7(4), 1-6 (2012).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 431.3 |
| 分子式 | C17H10F9NO2 |
| CAS号 | 1246525-60-9 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
